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Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise

Holmstrup, M., Fairchild, T.J.ORCID: 0000-0002-3975-2213, Keslacy, S., Weinstock, R. and Kanaley, J. (2013) Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise. Metabolism: Clinical and Experimental, 63 (4). pp. 510-519.

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Link to Published Version: http://dx.doi.org/10.1016/j.metabol.2013.12.006
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Abstract

Objective
Long, uninterrupted bouts of sedentary behavior are thought to negatively influence postprandial glucose and insulin concentrations. We examined the effects of a 1-h bout of morning exercise versus intermittent walking bouts of short duration on glucose excursions and insulin secretion over 12-h.

Materials/Methods
Eleven young, obese individuals (18–35 years, BMI > 30 kg/m2) with impaired glucose tolerance were studied on three 12-h study days: 1) sedentary behavior (SED); 2) sedentary behavior with 1-h morning exercise (EX) at 60%–65% VO2peak; and 3) sedentary behavior with 12-hourly, 5-min intervals of exercise (INT) at 60%–65% VO2peak. Meals (1046 kJ/meal) were provided every 2-h. Blood samples were collected every 10 min and measured for glucose, insulin, and c-peptide concentrations.

Results
Glucose iAUC (12-h) was attenuated in the INT and SED conditions compared to the EX condition (P < 0.05). Glucose concentrations were higher in the EX compared to the SED condition for ~ 150 min (20% of the study day), and comparison of the EX-INT study days revealed that glucose concentrations were greater for ~ 240 min (~ 1/3 of the 12-h day). In the SED condition, the 12-h insulin iAUC was ~ 15% higher (P < 0.05) compared to the INT and EX conditions. Insulin production rate was found to increase ~ 20% with INT exercise vs. the SED and EX condition (P < 0.05).

Conclusions
Short, frequent periods of exercise attenuated glucose excursions and insulin concentrations in obese individuals to a greater degree than an equal amount of exercise performed continuously in the morning.

Item Type: Journal Article
Murdoch Affiliation: School of Psychology and Exercise Science
Publisher: Elsevier
Copyright: Elsevier
URI: http://researchrepository.murdoch.edu.au/id/eprint/20695
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