Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Functional and morphological studies on blood platelets in a thrombasthenic horse

Sutherland, R.J., Cambridge, H. and Bolton, J.R. (1989) Functional and morphological studies on blood platelets in a thrombasthenic horse. Australian Veterinary Journal, 66 (11). pp. 366-370.

Link to Published Version:
*Subscription may be required


A four-year-old Standardbred gelding presented with a 3.5 year history of intermittent epistaxis and spontaneous submucosal petechiae and ecchymoses in the nares and the mouth. Routine haematological and biochemical examinations were unremarkable. A thrombocytopathy was suspected when activated partial thromboplastin time, one stage prothrombin time, plasma fibrinogen and the platelet count were all normal. The patient's platelets failed to aggregate with serotonin, adenosine diphosphate, collagen (at 20μg/ml) or the endoperoxide analogue U46619. Very high levels of collagen (100μg/ml) did cause aggregation. The response to the calcium ionophore A23187 was reduced and although complete degranulation occurred the resulting aggregates were unstable. Thromboxane generation in response to collagen and ADP was inferred from the concentration of its stable metabolite thromboxane B2 and was reduced. A diagnosis of a thrombasthenia-like syndrome possibly equivalent to Type II Glanzmann's thrombasthenia in people was made.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Wiley-Blackwell
Item Control Page Item Control Page