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Phosphorylase re-expression, increase in the force of contraction and decreased fatigue following notexin-induced muscle damage and regeneration in the ovine model of McArdle disease

Howell, J.Mc.C., Walker, K.R., Creed, K.E., Dunton, E., Davies, L., Quinlivan, R. and Karpati, G. (2013) Phosphorylase re-expression, increase in the force of contraction and decreased fatigue following notexin-induced muscle damage and regeneration in the ovine model of McArdle disease. Neuromuscular Disorders, 24 (2). pp. 167-177.

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Link to Published Version: http://dx.doi.org/10.1016/j.nmd.2013.10.003
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Abstract

McArdle disease is caused by a deficiency of myophosphorylase and currently a satisfactory treatment is not available. The injection of notexin into, or the layering of notexin onto, the muscles of affected sheep resulted in necrosis followed by regeneration of muscle fibres with the expression of both non-muscle isoforms of phosphorylase within the fibres and a reduction of the amount of glycogen in the muscle with an increase in the strength of contraction and a decrease in fatiguability in the muscle fibres. The sustained re-expression of both the brain and liver isoforms of phosphorylase within the muscle fibres provides further emphasis that strategies to enhance the re-expression of these isoforms should be investigated as a possible treatment for McArdle disease.

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology and Exercise Science
Publisher: Elsevier BV
Copyright: © 2013 Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/20053
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