Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Alpha-1 adrenoceptor stimulation triggers axon-reflex vasodilatation in human skin

Drummond, P.D.ORCID: 0000-0002-3711-8737 (2009) Alpha-1 adrenoceptor stimulation triggers axon-reflex vasodilatation in human skin. Autonomic Neuroscience, 151 (2). pp. 159-163.

PDF - Authors' Version
Download (167kB)
Link to Published Version:
*Subscription may be required


The aim of this study was to determine whether pre-treatment of human skin with the α1-adrenoceptor antagonist terazosin would block vasoconstrictor responses and axon-reflex vasodilatation to the α1-adrenoceptor agonist methoxamine. Drugs were administered by iontophoresis into the skin of the forearm of 15 healthy participants, and skin blood flow was monitored with a laser Doppler flow probe at the site of methoxamine iontophoresis (to monitor direct vasoconstrictor responses) or 5–10 mm from the site of methoxamine iontophoresis (to monitor axon-reflex vasodilatation). Experimental sites were pre-treated with terazosin (administered by iontophoresis for 10 min at 200 µA), and the same current intensity was passed through 0.9% saline to control for the nonspecific effects of iontophoresis. Pre-treatment with terazosin blocked vasoconstrictor responses to increasing doses of methoxamine, and also blocked vasodilatation several mm from the site of terazosin and methoxamine administration. These findings support the view that α1-adrenoceptors play a role in generating axon-reflex vasodilatation, and thus might contribute to local vascular disturbances in acute and chronic inflammation.

Item Type: Journal Article
Murdoch Affiliation(s): School of Psychology
Publisher: Elsevier
Copyright: Elsevier
Item Control Page Item Control Page


Downloads per month over past year