Avian reovirus proteins associated with neutralization of virus infectivity

Wickramasinghe, R., Meanger, J., Enriquez, C.E. and Wilcox, G.E. (1993) Avian reovirus proteins associated with neutralization of virus infectivity. Virology, 194 (2). pp. 688-696.

Abstract

Monoclonal antibodies against two virion proteins of the RAM-1 strain of avian reovirus neutralized virus infectivity; antibody against a 124-kDa(λB) protein caused broadly specific neutralization and antibody against a 39-kDa (σC) protein caused neutralization of greater type-specificity. The neutralizing activity of the monoclonals also exhibited host cell specificity: antibodies against the λB protein inhibited virus infectivity in Vero cells and not chicken kidney cells; one monoclonal antibody against the σC protein neutralized virus in only chicken kidney cells, whereas two other monoclonals against the σC protein neutralized virus in both Vero and chicken kidney cells but had greater neutralizing activity in Vero cells.

Item Type:	Journal Article
Murdoch Affiliation(s):	School of Veterinary Studies
Publisher:	Elsevier
URI:	http://researchrepository.murdoch.edu.au/id/eprint/19567

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