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The pathology and trace element status of the toxic milk mutant mouse

Howell, J.Mc.C. and Mercer, J.F.B. (1994) The pathology and trace element status of the toxic milk mutant mouse. Journal of Comparative Pathology, 110 (1). pp. 37-47.

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The toxic milk (tx) mouse is a mutant in which copper metabolism is abnormal. Homozygous tx adults do not show overt signs of disease, but litters born to such parents are deficient in copper and die at about 2 weeks of age unless copper is provided. The results reported here clearly indicate that adults accumulate copper in the liver, kidney, spleen, brain, muscle, serum and red blood cells. The concentration of zinc is also elevated in liver, brain and muscle. In adult animals there is damage to hepatocytes with marked changes to the nuclei. Haemolysis occurs with subsequent deposition of haemosiderin in the kidney. This mutant provides a useful model for studies of the pathogenesis and treatment of copper toxicity in animals and man.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: Elsevier BV
Copyright: © 1994 Published by Elsevier Ltd.
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