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Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus

Chadwick, B.J., Coelen, R.J., Sammels, L.M., Kertayadnya, G. and Wilcox, G.E. (1995) Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. Journal of General Virology, 76 (1). pp. 189-192.

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Jembrana disease virus, the cause of an acute, severe disease in Bali (Bos javanicus) cattle in Indonesia was recently identified as a retrovirus, and possibly a lentivirus. We have produced sequence data representing 598 bp of the pol gene, amplified by PCR from viral cDNA using broadly reactive universal primers for retroviruses and more specific genus-reactive primers for lentiviruses. When the sequence data were compared with that of known lentiviruses and other bovine retroviruses, the closest alignment was with bovine immunodeficiency-like lentivirus (BIV), showing 74% nucleotide sequence identity. This confirmed that JDV is a lentivirus and that it is distinguishable from BIV. The pathogenesis of Jembrana disease is most unusual for a lentivirus infection and differs markedly from that reported for BIV infection.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: Society for General Microbiology
Copyright: © 1995 SGM
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