Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus

Chadwick, B.J., Coelen, R.J., Sammels, L.M., Kertayadnya, G. and Wilcox, G.E. (1995) Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. Journal of General Virology, 76 (1). pp. 189-192.

Free to read: http://dx.doi.org/10.1099/0022-1317-76-1-189
*No subscription required

Abstract

Jembrana disease virus, the cause of an acute, severe disease in Bali (Bos javanicus) cattle in Indonesia was recently identified as a retrovirus, and possibly a lentivirus. We have produced sequence data representing 598 bp of the pol gene, amplified by PCR from viral cDNA using broadly reactive universal primers for retroviruses and more specific genus-reactive primers for lentiviruses. When the sequence data were compared with that of known lentiviruses and other bovine retroviruses, the closest alignment was with bovine immunodeficiency-like lentivirus (BIV), showing 74% nucleotide sequence identity. This confirmed that JDV is a lentivirus and that it is distinguishable from BIV. The pathogenesis of Jembrana disease is most unusual for a lentivirus infection and differs markedly from that reported for BIV infection.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Society for General Microbiology
Copyright: © 1995 SGM
URI: http://researchrepository.murdoch.edu.au/id/eprint/19376
Item Control Page Item Control Page