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Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

Cannizzaro, V., Berry, L.J., Nicholls, P.K.ORCID: 0000-0001-7071-3055, Zosk, G.R., Turner, D.J., Hantos, Z. and Sly, P.D. (2009) Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice. Respiratory Physiology & Neurobiology, 169 (3). pp. 243-251.

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The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume- (20 or 40 mL/kg) or pressure-controlled (25 cmH2O) RMs every 5 or 75 min for 150 min. The low-frequency forced oscillation technique was used to measure respiratory input impedance. Large RMs resulting in peak airway opening pressures (Pao) > 30 cmH2O did not increase inflammatory response or affect transcutaneous oxygen saturation but significantly lowered airway resistance, tissue damping and tissue elastance; the latter changes are likely associated with the bimodal pressure-volume behavior observed in mice. PEEP increase alone and application of RMs producing peak Pao below 25 cmH2O did not prevent or reverse changes in lung mechanics; whereas frequent application of substantial RMs on top of elevated PEEP levels produced stable lung mechanics without signs of lung injury.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Elsevier
Copyright: 2009 Elsevier B.V
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