The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

Hartaningsih, N., Dharma, D.M.N., Soeharsono, S. and Wilcox, G.E. (2001) The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens. Veterinary Immunology and Immunopathology, 78 (2). pp. 163-176.

Abstract

The ability to induce a protective immunity against Jembrana disease, an acute lentivirus disease of Bali cattle (Bos javanicus) present in Indonesia, was investigated. A protective immune response was induced in cattle by vaccination with virus-containing plasma and spleen tissue derived from acutely affected cattle. The virus was inactivated with Triton X-100 and emulsified in either incomplete Freund's adjuvant or a mineral oil adjuvant (MOA). The vaccination procedure suppressed the duration and severity of the disease but did not completely prevent the development of disease in animals challenged with 100 infectious doses of virus.

Item Type:	Journal Article
Murdoch Affiliation:	School of Veterinary and Biomedical Sciences
Publisher:	Elsevier BV
Copyright:	© 2001 Elsevier Science B.V.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/16993

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