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Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants

Jaensch, S., Cullen, L., Morton, L. and Raidal, S.R. (2001) Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 128 (2). pp. 181-187.

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The effects of oxygen exposure on pulmonary and blood non-enzymic antioxidant concentrations was evaluated in budgerigars (Melopsittacus undulatus). Budgerigars were exposed to acute (3 h), repeated acute (3 exposures each of 3 h) or chronic (72 h) normobaric hyperoxic environments and the pulmonary and plasma concentrations of selected non-enzymic antioxidants, namely glutathione, uric acid, α- and γ-tocopherol and carotenoids were assayed. With increasing duration of oxygen exposure, the ratio of oxidised to reduced glutathione was significantly increased, while the concentrations of uric acid, α- and γ-tocopherol and carotenoids were significantly reduced, especially following chronic oxygen exposure. Following acute and repeated acute exposure, alteration in glutathione concentrations and reduction in α-tocopherol concentrations indicated oxygen stress. Following chronic exposure, depletion of non-enzymic antioxidants indicated exhaustion of these protective mechanisms and progression from oxygen stress to oxygen toxicity.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Biomedical Sciences
Publisher: Elsevier Inc.
Copyright: © 2001 Elsevier Science Inc.
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