Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants

Jaensch, S., Cullen, L., Morton, L. and Raidal, S.R. (2001) Normobaric hyperoxic stress in budgerigars: non-enzymic antioxidants. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 128 (2). pp. 181-187.

Link to Published Version: http://dx.doi.org/10.1016/S1532-0456(00)00187-3
*Subscription may be required

Abstract

The effects of oxygen exposure on pulmonary and blood non-enzymic antioxidant concentrations was evaluated in budgerigars (Melopsittacus undulatus). Budgerigars were exposed to acute (3 h), repeated acute (3 exposures each of 3 h) or chronic (72 h) normobaric hyperoxic environments and the pulmonary and plasma concentrations of selected non-enzymic antioxidants, namely glutathione, uric acid, α- and γ-tocopherol and carotenoids were assayed. With increasing duration of oxygen exposure, the ratio of oxidised to reduced glutathione was significantly increased, while the concentrations of uric acid, α- and γ-tocopherol and carotenoids were significantly reduced, especially following chronic oxygen exposure. Following acute and repeated acute exposure, alteration in glutathione concentrations and reduction in α-tocopherol concentrations indicated oxygen stress. Following chronic exposure, depletion of non-enzymic antioxidants indicated exhaustion of these protective mechanisms and progression from oxygen stress to oxygen toxicity.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Elsevier Inc.
Copyright: © 2001 Elsevier Science Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/16978
Item Control Page Item Control Page