Alu polymorphism within the MICB gene and association with HLA-B alleles

Kulski, J.K., Dunn, D.S., Hui, J., Martinez, P., Romphruk, A.V., Leelayuwat, C., Tay, G.K., Oka, A. and Inoko, H. (2002) Alu polymorphism within the MICB gene and association with HLA-B alleles. Immunogenetics, 53 (10-11). pp. 975-979.

Abstract

We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.

Item Type:	Journal Article
Murdoch Affiliation(s):	Centre for Comparative Genomics School of Information Technology
Publisher:	Springer-Verlag
URI:	http://researchrepository.murdoch.edu.au/id/eprint/16736

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