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Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in the Northeastern Thais

Dunn, D.S., Romphruk, A.V., Leelayuwat, C., Bellgard, M. and Kulski, J.K. (2005) Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in the Northeastern Thais. Annals of Human Genetics, 69 (4). pp. 364-372.

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Polymorphic Alu insertions (POALINs) are known to contribute to the strong polymorphic nature of the Major Histocompatibility Complex (MHC). Previous population studies on MHC POALINs were limited to only Australian Caucasians and Japanese. Here, we report on the individual insertion frequency of the five POALINs within the MHC class I region, their HLA-A and B associations, and the three and four locus alpha block POALIN haplotype frequencies in the Northeastern (NE) Thai population. Of the five POALINs, the lowest frequency was 0.018 for AluyHF and the highest frequency was 0.292 for AluyHJ and AluyHG. The strongest positive associations between the POALINs and HLA class I alleles was between AluyMICB and HLA-B* 57, AluyHJ and HLA-A* 24 and HLA-A* 01, and AluyHG and HLA-A* 02, supporting previous findings in Caucasians and Japanese. Single POALIN haplotypes were found more frequently than multiple POALIN haplotypes. However, of the seven different POALIN haplotypes within the MHC alpha block, there were only two significant differences between the NE Thais, Caucasians and Japanese. This study confirms that the MHC POALINs are in linkage disequilibrium with HLA-A and -B alleles and that there are significant frequency differences for some of the POALINs when compared between NE Thai, Caucasians and Japanese.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Comparative Genomics
Publisher: Blackwell Publishing
Copyright: © University College London 2005.
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