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Impact of African herbal medicines on antiretroviral metabolism

Mills, E., Foster, B.C., van Heeswijk, R.P.G., Phillips, E., Wilson, K., Leonard, B., Kosuge, K. and Kanfer, I. (2005) Impact of African herbal medicines on antiretroviral metabolism. AIDS, 19 (1). pp. 95-97.

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We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.

Item Type: Journal Article
Publisher: Lippincott Williams & Wilkins Ltd.
Copyright: © 2005 Lippincott Williams & Wilkins, Inc.
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