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Classical swine fever virus vaccine stability in Lao PDR

Conlan, J., Vitesnik, T., Khounsy, S., Wilks, C. and Gleeson, L. (2008) Classical swine fever virus vaccine stability in Lao PDR. In: Conlan, J., Blacksell, S., Morrissy, C. and Colling, A., (eds.) Management of classical swine fever and foot-and-mouth disease in Lao PDR : proceedings of an international workshop held in Vientiane, Lao PDR, 20-21 November 2006. ACIAR Proceedings No. 128. ACIAR, Canberra, Australia, pp. 80-83.

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Classical swine fever (CSF) virus is a highly contagious but vaccine-preventable disease of swine. A locally produced lapinised C-strain vaccine is used to control CSF in Lao PDR; however, vaccine failure has been reported. The CSF vaccine is produced at the National Vaccine Production Centre (NVPC) as a freeze-dried rabbit spleen homogenate in a rubber stoppered glass vial and stored at –20 °C with a recommended shelf life of 1 year. This paper describes two studies to (i) determine the stability of the locally produced vaccine when stored at 4 °C and –20 °C and (ii) determine if the vaccine elicits a protective immune response when delivered to village pigs under good transport conditions. The vaccine was found to be stable for only 4 months when stored at –20 °C and for less than 3 months when stored at 4 °C. Under field conditions, vaccine stored at –20 °C for 2 months and transported at temperatures less than 1 °C elicited an immune response in 89% of vaccinated pigs by day 35 and 100% of pigs by day 70 post vaccination.

Item Type: Book Chapter
Publisher: ACIAR
Copyright: © Commonwealth of Australia 2008
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