Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra
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Loh, N.K., Lucas, M., Fernandez, S. and Prentice, D. (2012) Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra. Internal Medicine Journal, 42 (12). pp. 1358-1362.
Link to Published Version: http://dx.doi.org/10.1111/imj.12002
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Abstract
A previously healthy 20-year-old man presented with adult Still disease (ASD). He developed life-threatening macrophage activation syndrome (MAS), which was refractory to standard immunosuppression but responded dramatically to the IL-1 receptor antagonist anakinra. Subsequent immunological investigations included assessment of the perforin expression of natural killer (NK) cells and CD8+ T cells, which confirmed MAS.
| Item Type: | Journal Article |
|---|---|
| Murdoch Affiliation(s): | Centre for Clinical Immunology and Biomedical Statistics |
| Publisher: | Blackwell Publishing |
| Copyright: | © 2012 The Authors |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/12562 |
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