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In vivo efficacy of albendazole againstGiardia duodenalis in mice

Reynoldson, J.A., Thompson, R.C.A. and Meloni, B.P. (1991) In vivo efficacy of albendazole againstGiardia duodenalis in mice. Parasitology Research, 77 (4). pp. 325-328.

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The antigiardial effects of albendazole were demonstrated in vivo using experimental infections ofGiardia duodenalis in mice. These results complement previous in vivo studies in which albendazole was shown to have more potent antigiardial action than the currently applied antigiardial drugs. In mice, 2–4 doses (>100 mg/kg twice daily) were required for complete inhibition of cyst excretion and full elimination of trophozoites from the small intestine. The high doses necessary in mice were not unexpected and are discussed in light of the possible pharmacokinetics of albendazole in the animal model used in this study.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: Springer Verlag
Copyright: © 1991 Springer-Verlag.
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