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In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus

Thompson, R.C.A., Reynoldson, J.A. and Manger, B.R. (1991) In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus. Research in Veterinary Sciench, 51 (3). pp. 332-334.

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In vitro, epsiprantel at a concentration of 10 μg ml−1 caused tegumental damage and death of protoscoleces, juveniles (seven-day-old) and adult (37-day-old) Echinococcus granulosus. Degenerative changes and death occurred more rapidly in the older parasites. Similarly, epsiprantel was more effective against adult (28-day-old) than seven-day-old experimental infections of E granulosus in dogs. Oral doses of 2·5, 5 and 7·5 mg kg−1 were greater than 96 per cent, 99·9 per cent and 99·99 per cent active, respectively, against mature worms, whereas in seven-day-old infections doses of 5, 7·5 and 10 mg kg−1 produced greater than 94 per cent, 90 per cent and 99·8 per cent reduction in worm burdens, respectively. No side effects from treatment were seen.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary Studies
Publisher: W. B. Saunders Co., Ltd.
Copyright: © 1991 Published by Elsevier Ltd.
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