The efficacy of two electron transport inhibitors (720C80 and 993C76) on murine strongyloidiasis: A comparison with albendazole

Armson, A., Thompson, R.C.A., Reynoldson, J.A., Grubb, W.B. and Mendis, A.H.W. (1993) The efficacy of two electron transport inhibitors (720C80 and 993C76) on murine strongyloidiasis: A comparison with albendazole. International Journal for Parasitology, 23 (6). pp. 815-817.

Abstract

The clinical efficacy of albendazole (ABZ) in the treatment of chronic uncomplicated strongyloidiasis has been reported to be highly variable. In our murine model of strongyloidiasis a single oral dose of 5 and 10 mg kg-1 ABZ reduced (at day 4 post infection) the faecal larval count (FLC) by 54.2 ± 12.5% and 81.5 ± 10.2%, respectively. 100 mg kg-1 ABZ reduced the FLC by 100%. Two inhibitors of protozoan and filarial electron transport (720C80 and 993C76) inhibited the endogenous O2 consumption of intact infective (L3) larvae of S. ratti by > 50% at 2 x 10-5 M in vitro, and reduced the FLC by 72 ± 9.3% and 62.0 ± 10.3% respectively in vivo, at a dose of 70 mg kg-1. These results suggest that compounds designed as selective inhibitors of protozoan electron transport have significant efficacy against murine strongyloidiasis and may prove useful in the management of human strongyloidiasis.

Item Type:	Journal Article
Murdoch Affiliation(s):	School of Veterinary Studies
Publisher:	Elsevier BV
URI:	http://researchrepository.murdoch.edu.au/id/eprint/10669

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