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Vitamin B12 as a carrier for the oral delivery of insulin

Petrus, A.K., Vortherms, A.R., Fairchild, T.J.ORCID: 0000-0002-3975-2213 and Doyle, R.P. (2007) Vitamin B12 as a carrier for the oral delivery of insulin. ChemMedChem, 2 (12). pp. 1717-1721.

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The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral-enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral-enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin-B12 conjugates can significantly lower blood glucose levels when administered orally.

Item Type: Journal Article
Publisher: John Wiley and Sons Ltd
Copyright: © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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