Vitamin B12 as a carrier for the oral delivery of insulin
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Petrus, A.K., Vortherms, A.R., Fairchild, T.J.
ORCID: 0000-0002-3975-2213 and Doyle, R.P.
(2007)
Vitamin B12 as a carrier for the oral delivery of insulin.
ChemMedChem, 2
(12).
pp. 1717-1721.
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Abstract
The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral-enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral-enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin-B12 conjugates can significantly lower blood glucose levels when administered orally.
| Item Type: | Journal Article |
|---|---|
| Publisher: | John Wiley and Sons Ltd |
| Copyright: | © 2007 Wiley-VCH Verlag GmbH & Co. KGaA. |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/10597 |
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