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Publications: Keenan, Martine

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Number of items: 6.

Journal Article

Hargrove, T.Y., Wawrzak, Z., Alexander, P.W., Chaplin, J.H., Keenan, M., Charman, S.A., Perez, C.J., Waterman, M.R., Chatelain, E. and Lepesheva, G.I. (2013) Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: Structural basis for pathogen selectivity. Journal of Biological Chemistry, 288 (44). pp. 31602-31615.

Keenan, M., Alexander, P.W., Diao, H., Best, W.M., Khong, A., Kerfoot, M., Thompson, R.C.A., White, K.L., Shackleford, D.M., Ryan, E., Gregg, A.D., Charman, S.A., von Geldern, T.W., Scandale, I. and Chatelain, E. (2013) Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 1756-1763.

Keenan, M., Alexander, P.W., Chaplin, J.H., Abbott, M.J., Diao, H., Wang, Z., Best, W.M., Perez, C.J., Cornwall, S.M.J., Keatley, S.K., Thompson, R.C.A., Charman, S.A., White, K.L., Ryan, E., Chen, G., Loset, J-R, von Geldern, T.W. and Chatelain, E. (2013) Selection and optimization of hits from a high-throughput phenotypic screen againstTrypanosoma cruzi. Future Medicinal Chemistry, 5 (15). pp. 1733-1752.

Keenan, M., Chaplin, J.H., Alexander, P.W., Abbott, M.J., Best, W. M., Khong, A., Botero, A., Perez, C.J., Cornwall, S., Thompson, R.C.A., White, K.L., Shackleford, D.M., Koltun, M., Chiu, F.C.K., Morizzi, J., Ryan, E., Campbell, M., von Geldern, T.W., Scandale, I., Chatelain, E. and Charman, S.A. (2013) Two analogues of fenarimol show curative activity in an experimental model of chagas disease. Journal of Medicinal Chemistry, 56 (24). pp. 10158-10170.

Keenan, M., Abbott, M.J., Alexander, P.W., Armstrong, T., Best, W.M., Berven, B.M., Botero, A., Chaplin, J.H., Charman, S.A., Chatelain, E., von Geldern, T.W., Kerfoot, M., Khong, A., Nguyen, T., McManus, J.D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R.A., Wang, S.Z. and White, K.L. (2012) Analogues of Fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas Disease. Journal of Medicinal Chemistry, 55 (9). pp. 4189-4204.

Jacobs, R.T., Plattner, J.J. and Keenan, M. (2011) Boron-based drugs as antiprotozoals. Current Opinion in Infectious Diseases, 24 (6). pp. 586-592.

This list was generated on Thu Oct 23 00:16:18 2014 IST.