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Publications: Keane, Niamh

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Number of items: 30.

Journal Article

Keane, N.M., Pavlos, R.K., McKinnon, E., Lucas, A., Rive, C., Blyth, C.C., Dunn, D., Lucas, M., Mallal, S. and Phillips, E. (2014) HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity. AIDS, 28 (13). pp. 1891-1901.

Bronke, C., Almeida, C.M., McKinnon, E., Roberts, S.G., Keane, N.M., Chopra, A., Carlson, J.M., Heckerman, D., Mallal, S. and John, M. (2013) HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes. AIDS, 27 (6). pp. 899-905.

Keane, N., Almeida, C., Chopra, A., Cooper, D., Demaine, E., Mallal, S. and John, M. (2012) Early changes in the CD8 T Cell immunodominance hierarchy in primary HIV infection prior to seroconversion. Retrovirology, 9 (Suppl 2).

Keane, N., Almeida, C., Roberts, S., Ahmad, I., Mallal, S. and John, M. (2012) Evaluation of the dual IFNγ/IL-2 fluorospot-assay with flow cytometry for detection of HLA-restricted HIV-specific T-cell responses in HIV controllers. Retrovirology, 9 (Suppl 2). P243.

Keane, N.M., Roberts, S.G., Almeida, C.M., Krishnan, T., Chopra, A., Demaine, E., Laird, R., Tschochner, M., Carlson, J.M., Mallal, S., Heckerman, D., James, I. and John, M. (2012) High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection. Immunology and Cell Biology, 90 (2). pp. 224-234.

Keane, N.M. and John, M. (2011) Biomarkers of natural and vaccine immunity against HIV. Biomarkers in Medicine, 5 (2). pp. 113-116.

Almeida, C.M., Bronke, C., Roberts, S.G., McKinnon, E., Keane, N.M., Chopra, A., Kadie, C., Carlson, J., Haas, D. W., Riddler, S. A., Haubrich, R., Heckerman, D., Mallal, S. and John, M. (2011) Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes. The Journal of Immunology, 187 (5). pp. 2502-2513.

Almeida, C.M., Roberts, S.G., Laird, R., McKinnon, E., Ahmad, I., Keane, N.M., Chopra, A., Kadie, C., Heckerman, D., Mallal, S. and John, M. (2010) Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses. Vaccine, 28 (37). pp. 6052-6057.

Almeida, C.M., Roberts, S.G., Laird, R., McKinnon, E., Ahmad, I., Pfafferott, K., Turley, J., Keane, N.M., Lucas, A.D., Rushton, B.C., Chopra, A., Mallal, S. and John, M. (2009) Automation of the ELISpot assay for high-throughput detection of antigen-specific T-cell responses. Journal of Immunological Methods, 344 (1). pp. 1-5.

Keane, N.M., Roberts, S.G., Laird, R., Chopra, A., Krishnan, T., Almeida, C.M., Bronke, C., Mallal, S., James, I. and John, M. (2009) P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy. Retrovirology, 6 (Suppl 3, 22 October 2009). P128.

Price, P., Fernandez, S., Tan, D.B.A., James, I.R., Keane, N.M. and French, M.A. (2008) Nadir CD4 T-cell counts continue to influence interferon-γ responses in HIV patients who began antiretroviral treatment with advanced immunodeficiency. JAIDS Journal of Acquired Immune Deficiency Syndromes, 49 (4). pp. 462-464.

French, M.A., Keane, N.M., McKinnon, E.J., Phung, S. and Price, P. (2007) Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cells. HIV Medicine, 8 (3). pp. 148-155.

Burgess, K., Price, P., James, I.R., Stone, S.F., Keane, N.M., Lim, A.Y.F., Warmington, J.R. and French, M.A. (2006) Interferon-Gamma responses to candida recover slowly or remain low in immunodeficient HIV patients responding to ART. Journal of Clinical Immunology, 26 (2). pp. 160-167.

Price, P., Keane, N.M., Lee, S., Lim, A.F.Y., McKinnon, E.J. and French, M.A. (2006) A T2 cytokine environment may not limit T1 responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapy. Immunology, 119 (1). pp. 74-82.

Keane, N.M., Price, P., Lee, S., Almeida, C.A., Stone, S.F., James, I. and French, M.A. (2004) Restoration of CD4 T-cell responses to cytomegalovirus is short-lived in severely immunodeficient HIV-infected patients responding to highly active antiretroviral therapy. HIV Medicine, 5 (6). pp. 407-414.

Conference Paper

Keane, N.M., Pfafferott, K., Cooper, D., Roberts, S.G., Chopra, A., Demaine, E., Krishnan, T., Mallal, S. and John, M. (2010) HIV-1 adaptation to early HLA restricted immune responses in acute heterosexual transmission. In: 22nd Annual Conference of the Australasian Society for HIV Medicine, 20 - 22 October 2010, Sydney, Australia

Conference Item

Keane, N.M., Almeida, C., Chopra, A., Cooper, D., Demaine, E., Mallal, S. and John, M. (2012) Early changes in the CD8 T cell immunodominance hierarchy in primary HIV infection prior to seroconversion. In: AIDS Vaccine 2012, 9 - 12 September 2012, Boston, U.S.A.

Keane, N.M., Almeida, C., Roberts, S., Ahmad, I., Mallal, S. and John, M. (2012) Evaluation of the dual IFNγ/IL-2 Fluorospot-assay with flow cytometry for detection of HLA-restricted HIV-specific T-cell responses in HIV controllers. In: AIDS Vaccine 2012, 9 - 12 September 2012, Boston, U.S.A.

Phillips, E., Keane, N., Blyth, C., Lucas, A., Pavlos, R., Lucas, M., McKinnon, E. and Mallal, S. (2011) Both HLA Class I restricted CD8+ and Class II restricted CD4+T Cells are implicated in the pathogenesis of nevirapine hypersensitivity. In: 51st Interscience Conference of Antimicrobial Agents and Chemotherapy, 17 - 20 September 2011, Chicago, IL.

Almeida, C., Bronke, C., Roberts, S., McKinnon, E., Keane, N., Chopra, A., Kadie, C., Carlson, J., Haas, D., Riddler, S., Haubrich, R., Heckerman, D., Mallal, S. and John, M. (2010) HIV-1 adaptation leads to inflation of the HIV-specific CD8 T-cell response against HLA-adapted variant epitopes. In: Annual Meeting. Australasian Society for Immunology 2010, 5 - 9 December 2010, Perth, Western Australia.

Phillips, E., Lucas, M., Keane, N., Lucas, A., McKinnon, E. and Mallal, S. (2010) HLA-B*35 is associated with nevirapine hypersensitivity in the contemporary western australian HIV cohort study. In: 4th International Drug Hypersensitivity Meeting, 22 - 25 April 2010, Rome, Italy.

Tschochner, M., James , I., Almeida, C., Keane, N., Roberts, S., Bronke, C., Chopra, A., Maiden, T., Ahmad, I., Gaudieri, S., Mallal, S., Rauch, A., John, M., Furrer, H. and Günthard, H. (2009) Effects of HIV-1 immune selection on susceptability to integrase inhibitor resistance. In: 12th European AIDS Conference (EACS) 2009, 11 - 14 November 2009, Cologne, Germany.

Almeida, C., Bronke, C., Roberts, S., Cooper, D., Corkery, M., McKinnon, E., Ahmad, I., Keane, N., Chopra, A., Mallal, S., John, M. and Heckerman, D. (2009) Identification of multiple novel HIV-specific T-cell epitopes using HLA-associated HIV polymorphisms. In: 39th Annual Scientific Meeting of the Australasian Society for Immunology 2009, 6 - 10 December 2009, Gold Coast, QLD.

Keane, N., Roberts, S., Laird, R., Chopra, A., Krishnan, T., Almeida, C., Bronke, C., Mallal, S., James, I. and John, M. (2009) P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy. In: AIDS Vaccine 2009, 19 - 22 October 2009, Paris, France.

Roberts , S., Almeida, C., Bronke, C., Ahmad, I., Keane, N., Chopra, A., Mallal, S., John, M., Heckerman, D. and Mallal, S. (2009) Screening for HIV responses using optimal epitopes predicted by HLA-viral sequence polymorphism associations. In: 21st Annual Conference of the Australasian Society for HIV Medicine (ASHM), 9 - 11 September, Brisbane, Australia.

Netto, J., Keane, N., Mullaney, I., Nolan, D., Mallal, S. and Trengove, R. (2009) The alternate metabolism of abacavir and its role in immune-mediated hypersensitivity reactions in HIV infected individuals. In: 57th ASMS Conference on Mass Spectrometry and Allied Topics, 31 May - 4 June 2009, Philadelphia, USA.

Keane, N.M., Laird, R., Chopra, A., Maiden, T., Almeida, C., Mallal, S. and John, M. (2008) An HLA-C*0702 restricted T-Cell response directed against an immune escaped HIV NEF KY11 epitope exhibits higher functional avidity but lesser cytolytic activity when compared with the anti-wild type response. In: 20th Annual Australasian Society for HIV Medicine Conference, 17 - 20 September, Perth, Western Australia.

Keane, N.M., Laird, R., Chopra, A., Maiden, T., Almeida, C., Mallal, S. and John, M. (2008) HLA-Restricted T-cell responses to Immune-escape variants are detectable in chronic HIV-infection. In: AIDS Vaccine 2008, 13 - 16 October, Cape Town, South Africa.

Phillips, E., Rauch, A., Nolan, D., Martin, A., Almeida, C., Knowles, S., Shear, N., Cavassini, M., Harrigan, R., Montaner, J., Keane, N., Laird, R., Lucas, A. and Mallal, S. (2007) Genetic characterization of patients with MHC class I mediated abacavir hypersensitivity reaction. In: 4th International AIDS Conference on HIV Pathogenesis, Treatment and Prevention, 22 - 25 July, Sydney, Australia.

Keane, N., Lucas, A., Netto, J., Almeida, C., Martin, A., Marriott, D., Kelleher, A., Phillips, E., Nolan, D. and Mallal, S. (2007) Use of the ELISpot assay to detect abacavir- and nevirapine-induced IFN-g responses in PBMC from HIV-infected patients with abacavir or nevirapine hypersensitivity reactions. In: 4th International AIDS Conference on HIV Pathogenesis, Treatment and Prevention, 22 - 25 July, Sydney, Australia.

This list was generated on Thu Nov 27 04:25:13 2014 GMT.