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Stimulation of erythropoietin release by hypoxia and hypoxemia: Similar but different

Lee, C-J, Smith, D.W., Gardiner, B.S. and Evans, R.G. (2019) Stimulation of erythropoietin release by hypoxia and hypoxemia: Similar but different. Kidney International, 95 (1). pp. 23-25.

Link to Published Version: https://doi.org/10.1016/j.kint.2018.09.025
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Abstract

Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.

Publication Type: Journal Article
Murdoch Affiliation: School of Engineering and Information Technology
Publisher: Elsevier Inc
Copyright: © 2018 International Society of Nephrology.
URI: http://researchrepository.murdoch.edu.au/id/eprint/43146
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