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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa

Grifoni, A., Sidney, J., Carpenter, C., Phillips, E., Mallal, S., Scriba, T.J., Sette, A. and Lindestam Arlehamn, C.S. (2018) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa. Human Immunology, 79 (3). pp. 143-144.

Link to Published Version: https://doi.org/10.1016/j.humimm.2018.01.004
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Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, and -DRB1 loci. A minor deviation was detected at the HLA-DQB1 locus due to an excess of homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3425.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Elsevier BV
Copyright: © 2018 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics
URI: http://researchrepository.murdoch.edu.au/id/eprint/40288
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