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Evaluation of the sterility of single-dose medications used in a multiple-dose fashion

Martin, E.P., Mukherjee, J., Sharp, C.R. and Sinnott-Stutzman, V.B. (2017) Evaluation of the sterility of single-dose medications used in a multiple-dose fashion. Canadian Veterinary Journal, 58 (11). pp. 1187-1190.

Abstract

Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Canadian Veterinary Medical Association
Copyright: © Copyright 2017 Canadian Veterinary Medical Association
Publishers Website: https://www.canadianveterinarians.net/cvj-cjvr-cla...
URI: http://researchrepository.murdoch.edu.au/id/eprint/39972
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