Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
Al-Tamimi, M., Gardiner, E.E., Thom, J.Y., Shen, Y., Cooper, M.N., Hankey, G.J., Berndt, M.C., Baker, R.I. and Andrews, R.K. (2011) Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke. Stroke, 42 (2). pp. 498-500.
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Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Centre for Haemophilia and Thrombosis Research|
|Publisher:||American Heart Association|
|Copyright:||© 2011 American Heart Association, Inc.|
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