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Evaluation of echocardiography and cardiac biomarker concentrations in dogs with gastric dilatation volvulus

Aona, B.D., Rush, J.E., Rozanski, E.A., Cunningham, S.M., Sharp, C.R. and Freeman, L.M. (2017) Evaluation of echocardiography and cardiac biomarker concentrations in dogs with gastric dilatation volvulus. Journal of Veterinary Emergency and Critical Care, 27 (6). pp. 631-637.

Link to Published Version: https://doi.org/10.1111/vec.12667
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Abstract

Objective
To assess abnormalities in concentrations of cardiac troponin I (cTnI), lactate, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in relation to arrhythmias, echocardiographic measurements, and survival in dogs with gastric dilatation volvulus (GDV).

Design
Prospective observational study.

Setting
University hospital.

Animals
Twenty-two dogs with naturally occurring GDV.

Samples
Concentrations of cTnI, plasma lactate, and NT-proBNP were recorded at presentation to the emergency room, the time closest to echocardiography, and the highest recorded concentrations during hospitalization.

Interventions
None.

Measurements and Main Results
Cardiac rhythms were categorized on a 0–4 scale (0 = no ventricular premature complexes [VPCs], 1 = single VPCs, 2 = bigeminy or trigeminy, 3 = couplets or triplets, and 4 = R-on-T phenomenon or ventricular tachycardia). Echocardiography was performed 6–18 hours postoperatively. Fifteen dogs had ventricular arrhythmias during hospitalization (Grade 1 [n = 9], Grade 4 [n = 6]). The highest recorded cTnI concentration was significantly higher in the dogs with Grade 4 (P = 0.002) or Grade 1 (P = 0.001) arrhythmias compared to dogs without arrhythmias. Plasma lactate was significantly correlated with left ventricular internal diameter in diastole (r = −0.52, P = 0.01) and systole (r = −0.57, P = 0.006), left ventricular free wall in diastole (LWDd, r = 0.59, P = 0.004), and interventricular septal thickness in diastole (IVDs, r = 0.65, P = 0.001). Dogs that did not survive to 1 week postdischarge (3/22) had a significantly thicker LVWd (P = 0.04) and IVSd (P = 0.05), and received significantly less fluids in the first 24 (P = 0.02) and 48 hours (P = 0.03) of hospitalization.

Conclusions
Concentrations of cTnI and NT-proBNP increased during hospitalization, but only cTnI concentrations were significantly higher in dogs with a higher arrhythmia grade. Additional research on the potential role of serial measurement of biomarkers in dogs with GDV is warranted.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: Blackwell Publishing Inc.
Copyright: © Veterinary Emergency and Critical Care Society 2017
URI: http://researchrepository.murdoch.edu.au/id/eprint/39369
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