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Influence of host resistance on viral adaptation: hepatitis C virus as a case study

Gaudieri, S., Plauzolles, A. and Lucas, M. (2015) Influence of host resistance on viral adaptation: hepatitis C virus as a case study. Infection and Drug Resistance, 8 . pp. 63-74.

Free to read: https://doi.org/10.2147/IDR.S49891
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Abstract

Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pressure via protein–protein interactions and sequence-specific mutations. Specifically, we will present the “state of play” on viral escape mutations to host T-cell responses in the context of the hepatitis C virus, and their influence on infection outcome.

Publication Type: Journal Article
Publisher: Dove Press
Copyright: © 2015 Plauzolles et al.
URI: http://researchrepository.murdoch.edu.au/id/eprint/38821
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