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Postmortem diagnosis of canine diabetes mellitus and diabetic ketoacidosis via biochemical analysis of aqueous humour

Lim, Z., Stephens, N.S. and Gaál, T. (2015) Postmortem diagnosis of canine diabetes mellitus and diabetic ketoacidosis via biochemical analysis of aqueous humour. Veterinary Record Case Reports, 3 (1). e000187.

Link to Published Version: https://doi.org/10.1136/vetreccr-2015-000187
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Abstract

An adult male crossbreed canine cadaver of unknown age was presented for postmortem examination. The dog was found by animal welfare workers in a backyard, laterally recumbent with weak agonal breathing, which ceased during retrieval. No previous medical history was known. Postmortem urinalysis revealed hypersthenuria, severe bilirubinuria, severe glucosuria, significant haematuria and severe ketonuria (β-hydroxybutyrate). Serum biochemistry was not possible due to severe haemolysis; however analysis of aqueous humour revealed high concentrations of β-hydroxybutyrate, glucose, total bilirubin, urea and creatine. Severe diffuse hepatic lipidosis with severe intrahepatic cholestasis and jaundice, poor body condition and bilateral cataracts were identified on gross and histological examination. These findings are supportive of chronic diabetes mellitus with acute ketoacidosis resulting in death. As such, the authors propose that biochemical analysis of aqueous humour/ocular fluids can be considered for postmortem diagnosis of diabetes mellitus and diabetic ketoacidosis in dogs.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: BMJ Publishing Group
URI: http://researchrepository.murdoch.edu.au/id/eprint/38586
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