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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

Sulzer, D., Alcalay, R.N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W.H., Mao, X., Dawson, V.L., Dawson, T.M., Oseroff, C., Pham, J., Sidney, J., Dillon, M.B., Carpenter, C., Weiskopf, D., Phillips, E., Mallal, S., Peters, B., Frazier, A., Lindestam Arlehamn, C.S. and Sette, A. (2017) T cells from patients with Parkinson’s disease recognize α-synuclein peptides. Nature, 546 (7660). pp. 656-661.

Link to Published Version: https://doi.org/10.1038/nature22815
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Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Nature Publishing Group
URI: http://researchrepository.murdoch.edu.au/id/eprint/37682
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