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Limited acute CTL escape among three founder viruses in a case of acute heterosexual transmission of HIV-1 infections

Keane, N.M., Pfafferott, K., Cooper, D., Chopra, A., Roberts, S.G., Sterrett, S., Leary, S., Demaine, E., Krishnan, T., Mallal, S., Bar, K., Shaw, G. and John, M. (2011) Limited acute CTL escape among three founder viruses in a case of acute heterosexual transmission of HIV-1 infections. In: 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention., 17 - 20 July, 2011, Rome, Italy.

Abstract

New genome sequencing techniques have suggested that productive HIV-infection arises from a single founder virus in 80% of heterosexual transmissions. Viral adaptation to early HLA-restricted CTL responses has been described in several cases of acute infection. Here, we describe immunological and virological data from a case who presented in Fiebig stage II clade A HIV-infection, five days after an epidemiologically proven non-consensual sexual transmission.

Publication Type: Conference Item
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
URI: http://researchrepository.murdoch.edu.au/id/eprint/37467
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