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Towards a universal influenza virus vaccine eliciting broadly neutralising haemagglutinin antibodies

Berry, C.M. (2015) Towards a universal influenza virus vaccine eliciting broadly neutralising haemagglutinin antibodies. Journal of Vaccines & Vaccination, 06 (06).

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Link to Published Version: https://doi.org/10.4172/2157-7560.1000303
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Abstract

The surface haemagglutinin (HA) glycoprotein is the immunogenic target for most of the influenza virus immune responses and consists of a globular head and a stalk domain. Recent advances have been made towards the design of a universal influenza virus vaccine to protect against different virus strains based on conserved domains of the HA molecule eliciting broadly neutralising antibodies (bnAb). Development of a universal vaccine for influenza that induces long-lived cross-protective immunity would displace the need for annual seasonal vaccination; prediction of circulating strains and vaccine reformulation. Intense research efforts have been focused on enhancing the potency and breadth of vaccine-induced bnAbs. However, knowledge of how such bnAbs are generated and their mechanisms of action are scarce. Experimental 2-step vaccination approaches using prime-boost regimes stimulate the production of bnAbs but they are usually limited in potency and breadth. Adjuvant enhanced vaccination strategies to elicit potent bnAb and improved B cell memory responses will have an immense impact in global health care and pre-pandemic preparation.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: OMICS Publishing Ggroup
Copyright: © 2015 Berry CM.
URI: http://researchrepository.murdoch.edu.au/id/eprint/37334
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