Catalog Home Page

In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics

Longman-Jacobsen, N., Williamson, J.F., Dawkins, R.L. and Gaudieri, S. (2003) In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics. Gene, 312 . pp. 257-261.

Link to Published Version: https://doi.org/10.1016/S0378-1119(03)00621-8
*Subscription may be required

Abstract

Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Elsevier BV
Copyright: © Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/37296
Item Control Page Item Control Page