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Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8+ T cells correlates with 'memory inflation' in human cytomegalovirus infection

Northfield, J., Lucas, M., Jones, H., Young, N.T. and Klenerman, P. (2005) Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8+ T cells correlates with 'memory inflation' in human cytomegalovirus infection. Immunology and Cell Biology, 83 (2). pp. 182-188.

Link to Published Version: https://doi.org/10.1111/j.1440-1711.2005.01321.x
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Abstract

CMV-specific memory CD8+ T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes – a phenomenon termed 'memory inflation'. Using tetramer staining on samples from a large number of subjects and multivariate regression analysis, we were able to relate this to the phenotype of CD8+ T cells. We made the following observations: (i) CD85j (ILT-2/LIR-1) was highly expressed alongside CD57 – an established effector memory marker – on CMV-specific CD8+ T cells; (ii) on CD8+ T cells as a whole, with increasing age, CD57 and CD85j (ILT-2/LIR-1) expression increased whereas CCR7 expression decreased, indicating increasing maturation of the total CD8+ T-cell compartment with age; (iii) unit increases in the percentage of CMV-specific CD8+ T cells expressing CD57 and CD85j (ILT-2/LIR-1) were associated with incremental expansion of these T-cell populations; (iv) CMV seropositivity is associated with a marked effect on the overall phenotype of CD8+ T cells (at any given age, CMV seropositivity is associated with an 18.7% increase in CD85j (ILT-2/LIR-1) expression); and (v) from our observations we estimated from this an apparent 'ageing effect' of CMV on CD8+ T cells of 35.4 years. The data presented are consistent with a predictable, unidirectional and linear model of virus specific T-cell differentiation and maturation.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Nature Publishing Group
Copyright: © 2017 Australasian Society for Immunology
URI: http://researchrepository.murdoch.edu.au/id/eprint/37158
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