Catalog Home Page

Expression of CCR6 on B cells in systemic lupus erythematosus patients

Lee, A.Y.S., Bannan, J.L., Adams, M.J. and Körner, H. (2017) Expression of CCR6 on B cells in systemic lupus erythematosus patients. Clinical Rheumatology, 36 (6). pp. 1453-1456.

Link to Published Version: https://doi.org/10.1007/s10067-017-3652-3
*Subscription may be required

Abstract

B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: SpringerNature
Copyright: © 2017 Springer International Publishing AG
URI: http://researchrepository.murdoch.edu.au/id/eprint/37137
Item Control Page Item Control Page