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Screening of viral specific T-cell lines for HLA alloreactivity prior to adoptive immunotherapy may prevent GvHD

D'Orsogna, L.J.A., Roelen, D.L., Doxiadis, I.I.N. and Claas, F.H.J. (2011) Screening of viral specific T-cell lines for HLA alloreactivity prior to adoptive immunotherapy may prevent GvHD. Transplant Immunology, 24 (3). p. 141.

Link to Published Version: https://doi.org/10.1016/j.trim.2010.12.001
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Abstract

Immune deficiency and subsequent viral infection or reactivation is a common problem, particularly after stem cell transplantation. Virus specific T-cell adoptive immunotherapy across HLA barriers is increasingly being utilized as a treatment modality in immunocompromised patients. However, it was recently shown that nearly all viral specific memory T-cells are also allo-HLA reactive [1]. At least 45% of virus specific T-cell clones and most T-cell lines were shown to specifically crossreact against allogeneic HLA molecules. The allogeneic crossreactivity of CD8 and CD4 T-cells is directed primarily against HLA class I and II respectively [1–7], however, 3 viral specific CD8 T-cell clones have also been reported to exhibit allogeneic HLA class II crossreactivity [1,8]. As a consequence CD8 and CD4 T-cell adoptive immunotherapy across HLA barriers may be complicated by graft vs host disease (GvHD).

Publication Type: Journal Article
Publisher: Elsevier B.V.
Copyright: © 2010 Elsevier B.V
URI: http://researchrepository.murdoch.edu.au/id/eprint/37007
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