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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya

Arlehamn, C.S.L., Copin, R., Leary, S., Mack, S.J., Phillips, E., Mallal, S., Sette, A., Blatner, G., Siefers, H. and Ernst, J.D. (2017) Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya. Human Immunology, 78 (4). pp. 325-326.

Link to Published Version: http://dx.doi.org/10.1016/j.humimm.2017.03.007
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Abstract

One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci. A minor deviation was detected at the HLA-A locus due to an excess of HLA-A*02:02, 29:02, 30:02, and 68:02 homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3393.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Elsevier BV
Copyright: © 2017 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
URI: http://researchrepository.murdoch.edu.au/id/eprint/36207
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