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Cisplatin: synthesis of some 2,3-diaminopropionic ester analogues: dichloro(hexadecyl 2,3-diaminopropionato) platinum(II) and dichloro(cyclohexyl 2,3-diaminopropionato) platinum(II)

York, S.C., Firfiray, D.B., Giles, R.G.F., Thorton, D.A. and Watkins, G.M. (1987) Cisplatin: synthesis of some 2,3-diaminopropionic ester analogues: dichloro(hexadecyl 2,3-diaminopropionato) platinum(II) and dichloro(cyclohexyl 2,3-diaminopropionato) platinum(II). South African Journal of Chemistry, 40 (2). pp. 149-152.

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Abstract

The title compounds were prepared from ethyl cyanoacetate by the four-step procedure of conversion into the corresponding 2-hydroxyimino-derivative, transesterification with either hexadecanol or cyclohexanol, catalytic hydrogenation of the respective products to afford the diamino-dihydrochlorides, and complex formation of the latter pair with potassium tetrachloroplatinate. Assignment of the structures of the cis-platinum complexes was confirmed by infrared spectrometry.

Publication Type: Journal Article
Publisher: South African Bureau for Scientific Publications
Copyright: © 1987 South African Chemical Institute (SACI)
URI: http://researchrepository.murdoch.edu.au/id/eprint/35690
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