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Extended spectrum cephalosporins and Clostridium difficile

Golledge, C.L., McKenzie, T. and Riley, T.V. (1989) Extended spectrum cephalosporins and Clostridium difficile. Journal of Antimicrobial Chemotherapy, 23 (6). pp. 929-931.

Link to Published Version: http://dx.doi.org/10.1093/jac/23.6.929
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Abstract

There is little information about how commonly the newer cephalosporins cause diarrhoea due to Clostridium difficile. In this study of 111 patients with C. difficile-associated diarrhoea, 106 had received antimicrobial agents in the four weeks before detection of C. difficile. The relative risk for each antimicrobial agent was greatest with clindamycin, followed by cefotaxime, cephamandole and ceftriaxone. There was no statistically significant difference in risk between the cephalosporins evaluated. Narrower spectrum penicillins, anti-pseudomonal penicillins and aminoglycosides were not potent inciting agents.

Publication Type: Journal Article
Publisher: Oxford University Press
Copyright: © 1989 The British Society for Antimicrobial Chemotherapy
URI: http://researchrepository.murdoch.edu.au/id/eprint/35458
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