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Frequencies of resistance to Melaleuca alternifolia (tea tree) oil and rifampicin in Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Hammer, K.A., Carson, C.F. and Riley, T.V. (2008) Frequencies of resistance to Melaleuca alternifolia (tea tree) oil and rifampicin in Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. International Journal of Antimicrobial Agents, 32 (2). pp. 170-173.

Link to Published Version: http://dx.doi.org/10.1016/j.ijantimicag.2008.03.01...
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Abstract

This study was conducted to determine the frequencies at which single-step mutants resistant to tea tree oil and rifampicin occurred amongst the Gram-positive organisms Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. For tea tree oil, resistance frequencies were very low at <10-9. Single-step mutants resistant to tea tree oil were undetectable at two times the minimum inhibitory concentration (MIC) for S. aureus RN4220 and derivative mutator strains or at 3× MIC for the remaining S. aureus strains, including a clinical meticillin-resistant S. aureus isolate. Similarly, no mutants were recovered at 2× MIC for S. epidermidis or at 1× MIC for E. faecalis. Resistance frequencies determined in vitro for rifampicin (8× MIC) ranged from 10-7 to 10-8 for all isolates, with the exception of the S. aureus mutator strains, which had slightly higher frequencies. These data suggest that Gram-positive organisms such as Staphylococcus and Enterococcus spp. have very low frequencies of resistance to tea tree oil.

Publication Type: Journal Article
Publisher: Elsevier
Copyright: © 2008 Elsevier B.V. and the International Society of Chemotherapy
URI: http://researchrepository.murdoch.edu.au/id/eprint/35365
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