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Swainsonine toxicosis suppresses appetite and retards growth in weanling rats

Pritchard, D.H., Huxtable, C.R. and Dorling, P.R. (1990) Swainsonine toxicosis suppresses appetite and retards growth in weanling rats. Research in Veterinary Science, 48 (2). pp. 228-230.

Abstract

Two groups of weanling rats were treated with swainsonine, the toxin responsible for 'pea-struck' and locoism in grazing animals, for 21 days. The initial dose rate was 46 mg kg-1 d-1 in one group, and 7.6 mg kg-1 d-1 in the other. Food and water intake, urinary volume and bodyweight gain were recorded for each rat and compared with those for pair-fed and ad libitum fed control individuals. At both dose rates, swainsonine caused marked retardation of growth consequent to profound suppression of appetite. In intoxicated rats, intake of water was also diminished.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Harcourt Publishers Ltd
URI: http://researchrepository.murdoch.edu.au/id/eprint/34898
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