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Feline immunodeficiency virus replicates in salivary gland ductular epithelium during the initial phase of infection

Park, H.S., Kyaw-Tanner, M., Thomas, J. and Robinson, W.F. (1995) Feline immunodeficiency virus replicates in salivary gland ductular epithelium during the initial phase of infection. Veterinary Microbiology, 46 (1-3). pp. 257-267.

Link to Published Version: http://dx.doi.org/10.1016/0378-1135(95)00090-W
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Abstract

Feline immunodeficiency virus (FIV) antigen was detected by immunochemistry in salivary glands of cats experimentally inoculated with West Australian isolate T91. Six cats were inoculated subcutaneously with 1.0 ml of tissue culture supernatant fluid from a feline T-lymphoblastoid cell line (MYA-1) infected with T91. FIV antigens were detected in the interlobular ducts of the salivary gland of cats infected with FIV 2, 4 and 6 weeks previously. FIV antigen was not detected in the salivary glands of three FIV negative cats and one naturally infected cat. Further, FIV antigen was located only in interlobular duct epithelial cells. The distribution of FIV in the interlobular ducts confirms the important role of salivary glands as a major reservoir of FIV in the early phase of infection and strengthens suggestions that the salivary route is an important mode of transmission of FIV.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Elsevier BV
URI: http://researchrepository.murdoch.edu.au/id/eprint/33898
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