Detection of Helicobacter pylori antigen in faeces by enzyme immunoassay
Coombs, G.W., Foster, N.M., Pearman, J.W. and Forbes, G.M. (2001) Detection of Helicobacter pylori antigen in faeces by enzyme immunoassay. Pathology, 33 (4). pp. 496-497.
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The detection of Helicobacter pylori antigen directly in faecal specimens may offer an alternative non-invasive method for determining the presence of H. pylori infection. This study compared the performance of the Premier Platinum HpSA enzyme immunoassay (HpSA) with histology and CLOtest, a rapid urease test. Of 134 patients undergoing upper gastrointestinal endoscopy, 37 (28%) were H. pylori-positive by histology and CLOtest. Using the HpSA test, H. pylori was detected in 35 H. pylori-positive patients (95% sensitivity) and one H. pylori-negative patient (99% specificity). The positive and negative predictive values for HpSA were 97 and 98%, respectively. HpSA is a rapid, easily performed, non-invasive method for detecting H. pylori.
|Publication Type:||Journal Article|
|Publisher:||Taylor & Francis|
|Copyright:||© 2001 Royal College of Pathologists of Australasia.|
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