Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing
Cooper, D., Chopra, A., Blinco, J., Leary, S., Watson, M. and Mallal, S. (2015) Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing. In: Science on the Swan, 21 - 23 April 2015, Perth, Western Australia.
Several disease association studies indicate that, the interactions between the KIR and HLA loci may have a role in infectious diseases, autoimmune disorders, cancer and reproduction. Current typing methods for HLA Loci use PCR for whole gene amplification or selected exon amplification. The Killer cell immunoglobulin-like receptors (KIR) genes are polymorphic and the gene complex is polygenic with a varying number of inhibitory (iKIRs) and activating (aKIRs) receptors. Due to this complexity of the KIR locus, genotyping is not performed as routinely.
|Publication Type:||Conference Item|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
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