Extraintestinal colonisation by Serpulina pilosicoli in an experimentally inoculated pig
Hampson, D.J., Robertson, I.D. and Oxberry, S.L. (1998) Extraintestinal colonisation by Serpulina pilosicoli in an experimentally inoculated pig. In: 15th International Pig Veterinary Society Congress, 5 - 9 July, Birmingham, UK p. 54.
The intestinal spirochaete Serpulina pilosicoli colonises the porcine large intestine where characteristically, but not invariably, large numbers of these bacteria become attached by one cell end to the mucosa (4). This colonisation can induce a colitis and a diarrhoeal disease called intestinal spirochaetosis (IS). Besides pigs, IS occurs naturally in various species of birds, as well as in dogs and human beings. Recently, S. pilosicoli was isolated from the bloodstream of a series of debilitated and/or immunocompromised human patients, some of whom subsequently died (5). It is not known whether S. pilosicoli can also invade and colonise extraintestinal sites in pigs, whether immunosupression would be necessary for this to occur, nor what the clinical outcomes might be. The current experiment was undertaken to investigate these possibilities, using pigs inoculated intravenously with the spirochaete so as to maximise the opportunity for colonisation to occur.
|Publication Type:||Conference Paper|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
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