Chronic Cystoisospora belli infection in an immunocompetent Myanmar refugee – microscopy is not sensitive enough
Woon, S-A, Yang, R., Ryan, U., Boan, P. and Prentice, D. (2016) Chronic Cystoisospora belli infection in an immunocompetent Myanmar refugee – microscopy is not sensitive enough. BMC Infectious Diseases, 16 (1). Article number 221.
*No subscription required
Background: Cystoisosporiasis is an opportunistic infection seen more commonly in patients with acquired immunodeficiency syndrome. Although uncommon, Cystoisospora infection can occur in immunocompetent individuals but tend to be benign and self-limiting. Chronic infection however, has been described but diagnosis can often be challenging and requires a high clinical index of suspicion. Case presentation: We present a case of delayed diagnosis of Cystoisospora belli (C. belli) in an immunocompetent 28-year-old refugee from Myanmar. She had a history of chronic diarrhea where exhaustive investigations over many years failed to reveal a diagnosis. Cystoisospora belli cysts were finally detected in stool 4 years after investigation commenced, and PCR testing on stored colon biopsies amplified a molecular product with 99 % sequence homology to C. belli. The patient improved promptly with trimethoprim-sulfamethoxazole treatment. Conclusion: In the appropriate clinical context we suggest molecular testing for C. belli or an empirical therapeutic trial.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Life Sciences|
|Copyright:||© 2016 Woon et al.|
|Item Control Page|
Downloads per month over past year