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One naive T cell, multiple fates in CD8+ T cell differentiation

Gerlach, C., van Heijst, J.W.J., Swart, E., Sie, D., Armstrong, N., Kerkhoven, R.M., Zehn, D., Bevan, M.J., Schepers, K. and Schumacher, T.N.M. (2010) One naive T cell, multiple fates in CD8+ T cell differentiation. Journal of Experimental Medicine, 207 (6). pp. 1235-1246.

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The mechanism by which the immune system produces effector and memory T cells is largely unclear. To allow a large-scale assessment of the development of single naive T cells into different subsets, we have developed a technology that introduces unique genetic tags (barcodes) into naive T cells. By comparing the barcodes present in antigen-specific effector and memory T cell populations in systemic and local infection models, at different anatomical sites, and for TCR–pMHC interactions of different avidities, we demonstrate that under all conditions tested, individual naive T cells yield both effector and memory CD8+ T cell progeny. This indicates that effector and memory fate decisions are not determined by the nature of the priming antigen-presenting cell or the time of T cell priming. Instead, for both low and high avidity T cells, individual naive T cells have multiple fates and can differentiate into effector and memory T cell subsets.

Publication Type: Journal Article
Publisher: The Rockefeller University Press
Copyright: © 2010 Gerlach et al.
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