Demonstration of Human T Lymphotropic Virus Type I (HTLV-I)-Specific T Cell Responses from Seronegative and Polymerase Chain Reaction-Negative Persons Exposed to HTLV-I
Nishimura, M., Kermode, A.G., Clerici, M., Shearer, G.M., Berzofsky, J.A., Uchiyama, T., Wiktor, S.Z., Pate, E., Maloney, B., Manns, A., Blattner, W. and Jacobson, S. (1994) Demonstration of Human T Lymphotropic Virus Type I (HTLV-I)-Specific T Cell Responses from Seronegative and Polymerase Chain Reaction-Negative Persons Exposed to HTLV-I. Journal of Infectious Diseases, 170 (2). pp. 334-338.
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Human T lymphotropic virus type I (HTLV-I) is a human retrovirus etiologically linked to adult T-cell leukemiaand the progressive chronic neurologic disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Described is a method that measures the production of interleukin-2 from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I-infected persons. The peptides correspond to immunogenic regions of the HTLV-I Env and Tax proteins. Significantly, this assay demonstrated T cell responses to these HTLV-I peptides from coded PBL samples in 7 of 19 HTLV-I-seronegative polymerase chain reaction-negative persons known to have been exposed to HTL V-I but in none of 16 matched controls without risk factors for exposure (P = .007). The implications of this finding are discussed.
|Publication Type:||Journal Article|
|Publisher:||Oxford University Press|
|Copyright:||© 1994 Infectious Diseases Society of America|
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