Formal infectious diseases consultation is associated with decreased mortality in Staphylococcus aureus bacteraemia
Robinson, J.O., Pozzi - Langhi, S., Phillips, M., Pearson, J.C., Christiansen, K.J., Coombs, G.W. and Murray, R.J. (2012) Formal infectious diseases consultation is associated with decreased mortality in Staphylococcus aureus bacteraemia. European Journal of Clinical Microbiology & Infectious Diseases, 31 (9). pp. 2421-2428.
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To determine the impact of infectious diseases consultation (IDC) in Staphylococcus aureus bacteraemia. All MRSA bacteraemia and a random subset of MSSA bacteraemia were retrospectively analysed. Out of 599 SAB episodes, 162 (27%) were followed by an IDC. Patients with IDC were younger andmore frequently intravenous drug users, but fewer resided in a long-term care facility or were indigenous. Hospital length of stay was longer (29.5 vs 17 days, p<0.001), and endocarditis (19.1%vs 7.3%, p<0.001) and metastatic seeding (22.2% vs 10.1%, p<0.001) were more frequent in the IDC group; however, SAPS II scores were lower in the IDC group (27 vs 37, p<0.001). ICU admission rates in the two groups were similar. The isolate tested susceptible to empirical therapy more frequently in the IDC group (88.9%vs 78.0%, p00.003). Seven-day (3.1 vs 16.5%), 30-day (8.0%vs 27.0%) and 1-year mortality (22.2% vs 44.9%) were all lower in the IDC group (all p<0.001). Multivariate analysis showed that effective initial therapy was the only variable associated with the protective effect of IDC. In patients with SAB, all-cause mortality was significantly lower in patients who had an IDC, because of the higher proportion of patients receiving effective initial antibiotics.
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