Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia
Bennett, C.M., Coombs, G.W., Wood, G.M., Howden, B.P., Johnson, L.E.A., White, D. and Johnson, P.D.R. (2014) Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia. Epidemiology and Infection, 142 (03). pp. 501-511.
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Community-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P=0·005) in younger patients (23 vs. 52 years, P<0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.
|Publication Type:||Journal Article|
|Publisher:||Cambridge University Press|
|Copyright:||© 2013 Cambridge University Press.|
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