Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
White, K.D., Chung, W-H, Hung, S-L, Mallal, S. and Phillips, E.J. (2015) Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response. Journal of Allergy and Clinical Immunology, 136 (2). pp. 219-234.
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Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is associated with risk of severe reactions, highlighting the importance of T-cell immune responses in the mechanisms of both B cell–mediated and primary T cell–mediated IM-ADRs. In this review we summarize the role of host genetics, microbes, and drugs in IM-ADR development; expand on the existing models of IM-ADR pathogenesis to address multiple unexplained observations; discuss the implications of this work in clinical practice today; and describe future applications for preclinical drug toxicity screening, drug design, and development.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
|Copyright:||© 2015 Elsevier Inc|
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